Home Depot’s Organizational Culture Essay

As I would see it, Nardelli’s programs were fizzled in changing activity of Home Depot to an increasingly successful one. There are two reasons that Nardelli was not increasingly fruitful. To begin with, most workers would not like to a pariah to â€Å"GE-ize their organization and culture. † Employees in Home Depot didn't confide in their new director, which drove missing help when Nardelli completed the new procedure. The subsequent explanation was additionally the more significant explanation. Nardelli utilized the idea gained from mechanical organizations to lead the client organizations. Since Nardelli needed to direct Home Depot in his own methodology, he neglected to perceive the significance of bleeding edge staff, which leaded his fizzle in leading the retailing business. The thing he ought to have done was improve the flow of data between the various stores or inside various level. Just along these lines, he could tackle the difficult that Home Depot looked at that timeâ€too huge to be gainful. The most exceedingly awful thing he ought not have done was to dispose of numerous old representatives and supplanted the full clocks with low maintenance staff. This decrease in the nature of client support and consumer loyalty unequivocally hurt the client orientated business. 2. Nardelli gave a three-section system including improving Home Depot’s benefit, and growing the business and market. Crow concentrated on the other three needs which would resuscitate employees’ feeling of proprietorship, cultivate their item information, and lift their assurance. The best distinction was that Nardelli’s activities programs were focused on expanding benefit and extension, while Tim Crow’s programs were focused on expanding representatives. Nardelli’s activity diminished employees’ fulfillment and dependability, which demolished Home Depot’s solid client support culture. Tim Crow’s programs expanded employees’ devotion and resuscitated Home Depot’s hierarchical culture. 3. Solid culture mirrors the estimations of the organization’s originators. Home Depot’s authors: Bernard Marcus and Arthur Black, as business visionaries, accentuated on responsibility to clients, associates, and friends. These directed the first culture of Home Depot. Now and again, the authoritative culture could cause strife when top administration changed. When Nardelli toke over Home Depot, conflict of two particular social methodologies happened. Hierarchical culture that is comprised of shared convictions, qualities, and suspicions existed in the association would lead the conduct of workers and the heading of association. Home Depot’s unique culture let representatives to build up solid relationship with clients, however after Nardelli’s conduction, this relationship just as employees’ and reliability were hurt. Since the way of life would influence employees’ execution and organization’s accomplishment, it ought to be worked to fit the attributes of the business and changed with incredible consideration. Coordination, compromise, and money related achievement were the advantages of looking after culture. Anyway Nardelli neglected to accomplish these objectives. Tim Crow, then again, centered around reestablishing the underlying society by actualizing more worker grant programs that would decidedly affect representative dedication and execution.

Organizational Change and Innovation Research Paper

Authoritative Change and Innovation - Research Paper Example Organizations must improve so as to profit by new advances and assets to remain in front of their rivals. Advancement, in this manner, is seen as both a closures and a methods for making sure about upper hand. Authoritative advancement has, accordingly, been characterized as the procedure whereby associations take part in new item improvement or new employments of items and administrations that as of now exist. Before endeavoring to examine the difficulties of development as a change the board procedure, it is important to comprehend the different kinds of progress. Radical advancement characterizes the presentation of a totally new item or innovation that replaces a current one (Griffin, 2013). Steady development, then again, is changing a current item/innovation with a more up to date one (Griffin, 2013). Specialized advancement manages changes in the presentation, appearance or different parts of the item or of the procedures through which it is passed (Griffin, 2013). The board d evelopment alludes to changes in hierarchical structure or administrative procedures (Griffin, 2013). At long last, item development manages changes in the item instead of procedure advancement that manages adjustments in the dispersion, assembling or making of procedures (Griffin, 2013). ... Be that as it may, different organizations have neglected to advance inferable from different reasons. Like some other change, development also can be met with obstruction from inside the association. Besides, the absence of a supporting society and the absence of â€Å"fit† with the outside condition regularly render development futile. It is important the instances of organizations that neglected to advance effectively in light of the fact that they couldn't adjust to the outside condition. Sony is one such organization which fizzled with its â€Å"e-books† peruser which lost its fight against Amazon (Viardot, 2011) . It couldn't discover answers for the difficulties forced by the monetary and legitimate condition concerning the distributers and creators. The organization neglected to offer an answer for overseeing and securing advanced rights and couldn't plan a compelling on the web store. This is in opposition to the achievement that Amazon had in the succeeding a long time with its digital book administration â€Å"Kindle† which incomprehensibly was bulkier, bigger and had a littler screen contrasted with Sony’s Reader. Moreover, Kindle had constrained capacities in that it had the option to source content just from Amazon. In spite of these inadequacies, Kindle thrived in light of the fact that Amazon put together its incentive with respect to arrangement with the biological system. The organization, rather than constraining distributers to capitulate to the stage, gave them motivating forces to make them ‘want to’ become a piece of a progressive achievement (Sadowski, 2013). Contrasted with Sony, Amazon concentrated on the master plan and even yielded its benefits to produce volumes. Moreover, the accomplishment of advancements by organizations, for example, Apple have featured exactly that it is so imperative to accomplish adaptability regarding the outer condition. The company’s development iPod succeede d

The Adventures of Huckleberry Finn Essay Example for Free

The Adventures of Huckleberry Finn Essay In the novel, The Adventures of Huckleberry Finn by Mark Twain, the primary character, Huck Finn, experiences an assortment of encounters that transforms him as a man, associations with different characters in the novel and we get the opportunity to comprehend the author’s point of view through the characters. Huck Finn prospered from multiple points of view through the novel, The Adventures of Huckleberry Finn. Huck Finn grew up with the generalization that all blacks are useless and don't have the right to carry on with a similar way of life and have indistinguishable rights from any white man. His dad carries these perspectives to Huckleberry’s consideration. During the novel, Huck ventures to every part of the Mississippi waterway with a dark male slave named Jim, all through the excursion Huck figures out how to be benevolence and have sympathy for other people. By encountering various hindrances and circumstances, Huckleberry increases a knowledge into others’ lives and how their encounters vary from his. He figures out how to be increasingly open to new and various standpoints of life. He learns boldness, sympathy, empathy, and the contrasts among law and good and bad. In light of these encounters, Huck picks up mental fortitude and development. Huckleberry is a better than ever man before the finish of the novel. All through The Adventures of Huckleberry Finn, Mark Twain outlines the bond framed between Huck, the youthful white hero, and Jim, Hucks dark friend. Over the long haul Huck starts to acknowledge and see how dark men have been treated for the duration of their lives and begins to regard Jim increasingly more by who he really is. While Huck and Jim travel down the waterway it becomes obvious that Jim is even more a dad figure to Huck than his natural dad. Huck’s father, Pap, shows the excellencies of an actual existence not worth living, while Jim gives Huck the best possible protective help, empathy, and information for Huck to turn into a man. While Pap goes about as a grapple on Hucks heel, Jim opens up another world for Huck, and turns into his buddy and an asset of information. He finds the perfect blend of regard, love, and assurance in Jim. In spite of the fact that Jim isn't book savvy, he keeps up the basic qualities that Huck needs. Despite the fact that Huck and Jim originate from discrete racial foundations their time together permits them to outperform their ethnic isolation and become genuine companions, and family. Huck restores the regard and thankfulness to Jim by staying faithful to his obligation and helping him become a liberated person. Toward the finish of the novel, Huck considers Jim being the same as any white man and doesn’t have the right to be dealt with diversely something else. In The Adventures of Huckleberry Finn, perusers can distinguish Mark Twain’s image of Southern culture through the characters. Imprint Twain brutally subverts our general public in his novel by mocks religion, progress, and human instinct to uncover the blemishes and shortcomings behind American culture. Twain condemns religion in the public eye through caricaturizing Miss Watson and Silas Phelps for being profoundly strict yet deceptive figures. Twain expresses that strict individuals can be wolves in sheep's clothing in circumstances, for example, in his novel, where they intentionally overlook certain lessons of their religion. The Bible energizes that individuals treat others they wish to be dealt with, and here Miss Watson conspicuously disregards that by being a slave proprietor. Despite the fact that numerous schools and guardians would disallow perusing this novel as a result of its language and malignance, Twain expresses that he composes reality. Huck is incredulous of numerous things and individuals in this novel. He infers that people comprehend and appreciate the world by various methods and depend on various sources to give reality. Individuals utilize their faculties, thinking, feeling, past encounters and what others have instructed them to comprehend the world and how to settle on their own choices. To comprehend something for what it is genuinely is you have to get an alternate point of view on it, which is the thing that Huck did with Jim to discover the genuine importance to bondage and to regard. The Adventures of Huckleberry Finn is an exemplary story where perusers find out about the genuine significance of companionship and servitude just by a white man and a dark man cruising down a stream to discover opportunity.

What is the significance of Mademoiselle Diana in Henrik Ibsen’s “Hedda Gabler” - Literature Essay Samples

Henrik Ibsen’s Hedda Gabler reflects the life of the eponymous protagonist against the backdrop of a wealthy upper middle class Norwegian city in the nineteenth century. During this time, there were clear social structures and traditions shown through the significant female characters and their roles within society: Hedda is on top of the social ladder since she is a wealthy, aristocratic wife, Mrs. Elvsted is â€Å"below† her socially because she is an adulterer and that she did not marry a high class man, and at the bottom is Mademoiselle (Mlle) Diana, â€Å"the fallen woman,† a madam who runs a brothel. Because of this contrast, Hedda and Mlle Diana are set out to be in different circles of society, but as the play goes on, their similarities are drawn out and the details suggest that Mlle Diana is indeed a form of foil for Hedda. Although both Mlle Diana and General Gabler are absent characters, General Gabler conforms to societal expectations whereas Mlle Diana does not fit the mold, making her important as the foil Hedda wants to suppress in order to conform to society. Near the beginning of the play, Mrs. Elvsted mentions the presence of a woman who â€Å"wanted to shoot [Là ¸vborg] with a pistol†. From Hedda’s reaction, there is ambiguity regarding the woman’s identity as Ibsen implies that Mrs. Elvsted mistook Hedda for Mlle Diana. This ambiguity is the start of a series of similarities between the two women: Hedda and Mlle Diana are both currently back in town after being absent for a while and both are interested in sexual liberation. In brief, Mlle Diana is the manifestation of the life Hedda could have had if she was not bound by social expectations, making her Hedda’s so-called alter ego or foil. Ibsen also constructs Mlle Diana to be a symbol of death and destruction. Very early on in the play, Mrs. Elvsted foreshadows a â€Å"red-haired singer†, creating an anticipative mood. The anticipative and mysterious mood is furthered by an element of dramatic irony where Mrs. Elvsted does not know that the woman is in fact Hedda, but both Hedda and the audience know her identity. Once again, Hedda and Mlle Diana are similar enough to be mixed up by another character, supporting the interpretation of Mlle Diana being Hedda’s foil. The audience recognizes that Mlle Diana is presented as a threat to Mrs. Elvsted’s and Là ¸vborg’s relationship from the very start, which could lead to the destruction of their bond, thus implying that she is a symbol of havoc. Ibsen introduces Mlle Diana as an obstacle perhaps to foreshadow Hedda later burning the manuscript, leading to the actual ruin of Mrs. Elvsted’s and Là ¸vborg’s relationship. Through Hedda’s destructive aspects, such as the act of burning the manuscript and her possession of firearm, Ibsen sets her as a symbol of havoc alongside with Mlle Diana. The dangerous elements of both women foreshadow the scene of Là ¸vborg’s death at Mlle Diana’s boudoir later on in the play. Thus, another link is established between Hedda and Mlle Diana that could imply Mlle Diana is Hedda’s foil. Moreover, Ibsen refers to Mlle Diana entirely through the dialogues between Hedda and Mrs. Elvsted, then between Hedda and Judge Brack. Every time she is mentioned explicitly, the color red appears: Mrs. Elvsted describes her as a â€Å"red-haired singer† and Judge Brack later confirms that she is a â€Å"red-haired woman†. The color red has traditional connotations of passion and has a significant link to fire, the force of nature that Hedda uses to burn the manuscript and threatens to â€Å"burn [Mrs. Elvsted’s hair] off† with. As a result, the color red implies both strong emotions and the devastating actions that come with those emotions. Since Mlle Diana is the only character with red hair in â€Å"Hedda Gabler†, she is the most visual symbol of destruction. Also, since the destructive actions associated with fire are mainly performed by Hedda and because she is so closely connected with it, Mlle Diana could be seen as a visual representation o f Hedda’s fiery spirit, making it likely that she could be Hedda’s foil. Mlle Diana’s fire-like appearance suggests an openness Hedda must not show. The expectations of conformity to society are mentioned many times in the play when the higher-class people (e.g. Hedda and Judge Brack) say â€Å"people don’t do that kind of thing here†, referring to unconventionally dramatic actions. So however intense her personality is, as a woman and an aristocrat, Hedda has to conceal it to fit in. Nevertheless, Ibsen projects Hedda’s passion onto her foil Mlle Diana who can be completely true to herself, both mentally and physically. After Mrs. Elvsted’s descriptions of Mlle Diana, Judge Brack mentions the men’s â€Å"party† in her boudoir. In Norway’s 1800s conservative culture, the higher one’s class was, the subtler one had to be regarding taboos such as sex, particularly for women. People who indulged in debauchery and openly sexual acts were condemned, much like how Hedda â€Å"broke it off† with the then-alcoholic Là ¸vborg. However, Hedda has always wanted to â€Å"have a glimpse† of this secret world, hinted by her exchanges with Judge Brack of the men’s â€Å"gay† party and her acceptance of the â€Å"cock in the yard† arrangement with him. Her curiosity shows an inclination towards sexual freedom, something she cannot attain with her social status. This desire is embodied by Mlle Diana and the fact that she is a madam: she has direct ties with the taboo sexual world. What Hedda cannot achieve, Mlle Diana is perfectly experienced in. After Mrs. Elvsted’s dialogue with Hedda about Mlle Diana, Judge Brack reveals Mlle Diana’s name to be a symbol since Diana is the Roman goddess of the hunt, nature, and fertility. This mythological allusion is referred to directly by her description as â€Å"a mighty huntress – of men.† â€Å"Huntress† is connected with her mythological namesake: the goddess Diana’s tale of shooting an arrow at Orion. The cruel irony is mirrored in Là ¸vborg’s death in Mlle Diana’s â€Å"boudoir†. Ibsen even presents the alternative of Mlle Diana potentially murdering him, emphasizing how â€Å"she’s quite equal to that†. Interpreting Mlle Diana as Hedda’s foil, his death in Mlle Diana’s boudoir is reasonable because Hedda wanted him to die previously, implied by her premeditated act of handing him â€Å"one of the pistols†. It is no coincidence that Lovborg’s death has to take place in Mlle Dia na’s boudoir; she can turn Hedda’s wish for his demise true, whether by accident or not. Therefore, Mlle Diana is an alter ego that embodies Hedda’s innermost destructive desires and can enact them when Hedda cannot. Because of Là ¸vborg’s death towards the end of the play, Hedda will have to â€Å"appear in court [†¦] with Mademoiselle Diana.† With this final meeting, the presence of Mlle Diana becomes much more apparent than before. Ibsen develops the plot so that as the play goes on, Mlle Diana gets closer to Hedda. This progression starts with Mrs. Elvsted’s account of Mlle Diana, then to Judge Brack’s announcement of Là ¸vborg’s death in her boudoir, and finally to Judge Brack threatening Hedda with Diana’s physical presence. The fact that it is a progression could imply how Hedda tries to suppress her foil because of societal pressures, but eventually concedes because she is tired of being â€Å"an awful coward†. The progression of Hedda meeting her foil follows Hedda’s progression from being a respectable married woman descending to be morally questionable with the burning of the manuscript. There is a parallel between Heddaâ⠂¬â„¢s proximity to Mlle Diana and her descent towards suicide, hinting at their connection as a character and a foil. Interpreting Mlle Diana as Hedda’s foil, Hedda’s sudden suicide is elucidated in a new light. If the encounter between them occurs, Hedda will have to acknowledge that although Mlle Diana represents all that she longs to â€Å"have a glimpse of†, this life does not end with a happy ending either. Disillusioned to the fullest extent, the only way to escape a reality so cruel is to end her life altogether. Ibsen builds Mlle Diana as a one-dimensional character to highlight her significance as a symbol of death and destruction, shown by her red hair and the mythological allusion of her name. He develops the metaphor further to turn her into a form of alternate reality for Hedda. Mlle Diana’s similarities with Hedda are shown through the chromatic imagery of her hair being connected with Hedda’s fiery spirit, them both having been in a relationship with Là ¸vborg, and their common interest in sexual liberation. By interpreting her as Hedda’s foil after considering their similarities and differences, the reader knows more about the life Hedda would have wanted if she did not conform to societal constraints. This alternative perspective on Hedda gives more insight into the social constraints during nineteenth century Norway and makes her a much more complex character than meets the eye.

The Human Genome Project And Encyclopedia Of Dna Elements

Understanding our life as we know it must start at the basics with our own DNA. DNA is the building blocks for all life, so to understand life we must analyze the mechanism of genetics. Projects like the Human Genome project and Encyclopedia of DNA elements (ENCODE) analyzes DNA to give society an interpretation of what the building code is and means. Our genetic code holds coding and non-coding sequences, at first researchers focused solely on coding DNA for it carried the function and means to life. The other non-coding was for years considered to be junk but in this review it will be highlighted by the example of Transposable elements that this so called useless DNA holds many secrets and keys to life. It is now recognized that genomic changes are influenced by transposable elements which has changed the way it is thought how genomes evolve and work. DNA Introduction Deoxyribonucleic acid, the building blocks for about all living creatures on Earth. Almost every cell in the human body shares the same DNA. Since DNA is practically the blueprint for living organisms, understanding the blueprint is crucial to a better understanding of the phenomena of our own bodies and the relationship between genetic variation and disease risk hopefully leading to the cure of many diseases, the prevention of harmful mutations, and possibly an explanation to our creation. This DNA is all the information for one’s body and is stored as a code with 4 chemical bases. As seen in theShow MoreRelatedEssay on The Human Genome Project1437 Words   |  6 Pagesdeeply in our body is the complex biological story. The Human Genome Project is the exploration of this intricate yet crucial storyline. The Genome is a complete set of genes that make up an organism. Genes are made up of DNA (deoxynucleic acid) which subsequently is made up of long paired strands. These paire d strands attach in a specific manner, for example, Adenine (A) attaches itself to Thymine (T) and Cytosine(C) to Guanine (G). The genome is the perplexing key in instructing cells to do theirRead MoreHow The Firm Strategy Affect The Emergence Of The Genomic Industry?1489 Words   |  6 Pagesanalysis of an individual’s genome. The industry can create a new avenue of approach in which it may profit through the production of tailored products and insights through the study of individual genome. This will also allow for the development of new technology and growth. Because of the necessity of a great quantity of diverse phenotypic and genomic data, this industry firm strategy will also consider genome databases and direct to consumer (DTC) genetic testing. Genome databases will give companiesRead MoreBiological Networks And The Biomedical And Genomic Fields962 Words   |  4 Pagesare ENCODE (Encyclopedia of DNA Elements) and TCGA (The Cancer Genome Atlas). The ENCODE project14, 15 was launched to identify all functional elements in the human genome - regions of transcription, transcription factor association, chromatin structure and histone modification. The ENCODE project has generated more than 6000 genomic datasets from ChIP-seq, RNA-seq, DNase-seq, shRNA knockdown followed by RNA-seq (The ENCODE Project Consortium, 2015). The pilot phase of the ENCODE project involved 440Read MoreThe Encyclopedia Of Dna Elements2407 Words   |  10 Pages The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential output from genomesRead MoreGenome Decoding: A Review of Three Articles1724 Words   |  7 Pagesthen states the reason why this newspaper gave a better version of the covered story among others based on the tendency (context), the information giving, and the supported arguments that this newspaper have. Genome Decoding: A review of three articles on the subject Introduction Genome Decoding is one of the most recent tantalizing scientific discoveries that have recently appeared in the news. Scientists have discovered that the 20,000 genes that do not code for proteins (and were, thereforeRead MoreAnnotated Bibliography On The Rna Profiling1999 Words   |  8 Pagesthe genome functions also. These observation are taken up together to form and define the functions and description related to genes (Bell, 2004). This observation tells about the range of expression and localization. As the technology is been improving day by day for the RNA profiling and the type of isolation made by the cells , the number of RNA has grown and has increase the biological function in an fast and immediate rate. The ENCODE project also known as the Encyclopedia of DNA element projectRead MoreCharacteristics Of The Functional Area Of Human Genome2127 Words   |  9 Pagessegment of human genome is formed of protein sequences while some of the non coded DNA indicates biologica l functions. Along with the coding of genomes, they are also consisted of sequence which is transcript into RNA like tRNA, rRNA .New challenges of these sequences in the non protein are most prevalent. They are known to identify the functional area in the human genome which is studied by (ENCODE) project. The characteristics which are acting upon the regulatory variations amongst the human beingsRead MoreAnnotated Bibliography On The Landscape Of Transcription2715 Words   |  11 PagesLANDSCAPE OF TRANSCRIPTION IN HUMAN CELLS INTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and geneRead MoreThe Encyclopedia Of Dna Elements2709 Words   |  11 PagesINTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential outputRead MoreSilico Characterization Of The Association Between Rs12670798 And Ldl Cholesterol2868 Words   |  12 PagesIntroduction Complex diseases are caused by multiple genetic and environmental factors working in combination with each other and thus, it is difficult to characterise the contribution of any one factor to the disease1. However, the widespread adoption of genome-wide association studies (GWAS) has greatly accelerated the rate at which these factors are discovered and characterised. These studies genotype individuals with different phenotypes (for example, those who are affected or unaffected by a complex

The Human Genome Project And Encyclopedia Of Dna Elements

Understanding our life as we know it must start at the basics with our own DNA. DNA is the building blocks for all life, so to understand life we must analyze the mechanism of genetics. Projects like the Human Genome project and Encyclopedia of DNA elements (ENCODE) analyzes DNA to give society an interpretation of what the building code is and means. Our genetic code holds coding and non-coding sequences, at first researchers focused solely on coding DNA for it carried the function and means to life. The other non-coding was for years considered to be junk but in this review it will be highlighted by the example of Transposable elements that this so called useless DNA holds many secrets and keys to life. It is now recognized that genomic changes are influenced by transposable elements which has changed the way it is thought how genomes evolve and work. DNA Introduction Deoxyribonucleic acid, the building blocks for about all living creatures on Earth. Almost every cell in the human body shares the same DNA. Since DNA is practically the blueprint for living organisms, understanding the blueprint is crucial to a better understanding of the phenomena of our own bodies and the relationship between genetic variation and disease risk hopefully leading to the cure of many diseases, the prevention of harmful mutations, and possibly an explanation to our creation. This DNA is all the information for one’s body and is stored as a code with 4 chemical bases. As seen in theShow MoreRelatedEssay on The Human Genome Project1437 Words   |  6 Pagesdeeply in our body is the complex biological story. The Human Genome Project is the exploration of this intricate yet crucial storyline. The Genome is a complete set of genes that make up an organism. Genes are made up of DNA (deoxynucleic acid) which subsequently is made up of long paired strands. These paire d strands attach in a specific manner, for example, Adenine (A) attaches itself to Thymine (T) and Cytosine(C) to Guanine (G). The genome is the perplexing key in instructing cells to do theirRead MoreHow The Firm Strategy Affect The Emergence Of The Genomic Industry?1489 Words   |  6 Pagesanalysis of an individual’s genome. The industry can create a new avenue of approach in which it may profit through the production of tailored products and insights through the study of individual genome. This will also allow for the development of new technology and growth. Because of the necessity of a great quantity of diverse phenotypic and genomic data, this industry firm strategy will also consider genome databases and direct to consumer (DTC) genetic testing. Genome databases will give companiesRead MoreBiological Networks And The Biomedical And Genomic Fields962 Words   |  4 Pagesare ENCODE (Encyclopedia of DNA Elements) and TCGA (The Cancer Genome Atlas). The ENCODE project14, 15 was launched to identify all functional elements in the human genome - regions of transcription, transcription factor association, chromatin structure and histone modification. The ENCODE project has generated more than 6000 genomic datasets from ChIP-seq, RNA-seq, DNase-seq, shRNA knockdown followed by RNA-seq (The ENCODE Project Consortium, 2015). The pilot phase of the ENCODE project involved 440Read MoreThe Encyclopedia Of Dna Elements2407 Words   |  10 Pages The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential output from genomesRead MoreGenome Decoding: A Review of Three Articles1724 Words   |  7 Pagesthen states the reason why this newspaper gave a better version of the covered story among others based on the tendency (context), the information giving, and the supported arguments that this newspaper have. Genome Decoding: A review of three articles on the subject Introduction Genome Decoding is one of the most recent tantalizing scientific discoveries that have recently appeared in the news. Scientists have discovered that the 20,000 genes that do not code for proteins (and were, thereforeRead MoreAnnotated Bibliography On The Rna Profiling1999 Words   |  8 Pagesthe genome functions also. These observation are taken up together to form and define the functions and description related to genes (Bell, 2004). This observation tells about the range of expression and localization. As the technology is been improving day by day for the RNA profiling and the type of isolation made by the cells , the number of RNA has grown and has increase the biological function in an fast and immediate rate. The ENCODE project also known as the Encyclopedia of DNA element projectRead MoreCharacteristics Of The Functional Area Of Human Genome2127 Words   |  9 Pagessegment of human genome is formed of protein sequences while some of the non coded DNA indicates biologica l functions. Along with the coding of genomes, they are also consisted of sequence which is transcript into RNA like tRNA, rRNA .New challenges of these sequences in the non protein are most prevalent. They are known to identify the functional area in the human genome which is studied by (ENCODE) project. The characteristics which are acting upon the regulatory variations amongst the human beingsRead MoreAnnotated Bibliography On The Landscape Of Transcription2715 Words   |  11 PagesLANDSCAPE OF TRANSCRIPTION IN HUMAN CELLS INTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and geneRead MoreThe Encyclopedia Of Dna Elements2709 Words   |  11 PagesINTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential outputRead MoreSilico Characterization Of The Association Between Rs12670798 And Ldl Cholesterol2868 Words   |  12 PagesIntroduction Complex diseases are caused by multiple genetic and environmental factors working in combination with each other and thus, it is difficult to characterise the contribution of any one factor to the disease1. However, the widespread adoption of genome-wide association studies (GWAS) has greatly accelerated the rate at which these factors are discovered and characterised. These studies genotype individuals with different phenotypes (for example, those who are affected or unaffected by a complex

The Human Genome Project And Encyclopedia Of Dna Elements

Understanding our life as we know it must start at the basics with our own DNA. DNA is the building blocks for all life, so to understand life we must analyze the mechanism of genetics. Projects like the Human Genome project and Encyclopedia of DNA elements (ENCODE) analyzes DNA to give society an interpretation of what the building code is and means. Our genetic code holds coding and non-coding sequences, at first researchers focused solely on coding DNA for it carried the function and means to life. The other non-coding was for years considered to be junk but in this review it will be highlighted by the example of Transposable elements that this so called useless DNA holds many secrets and keys to life. It is now recognized that genomic changes are influenced by transposable elements which has changed the way it is thought how genomes evolve and work. DNA Introduction Deoxyribonucleic acid, the building blocks for about all living creatures on Earth. Almost every cell in the human body shares the same DNA. Since DNA is practically the blueprint for living organisms, understanding the blueprint is crucial to a better understanding of the phenomena of our own bodies and the relationship between genetic variation and disease risk hopefully leading to the cure of many diseases, the prevention of harmful mutations, and possibly an explanation to our creation. This DNA is all the information for one’s body and is stored as a code with 4 chemical bases. As seen in theShow MoreRelatedEssay on The Human Genome Project1437 Words   |  6 Pagesdeeply in our body is the complex biological story. The Human Genome Project is the exploration of this intricate yet crucial storyline. The Genome is a complete set of genes that make up an organism. Genes are made up of DNA (deoxynucleic acid) which subsequently is made up of long paired strands. These paire d strands attach in a specific manner, for example, Adenine (A) attaches itself to Thymine (T) and Cytosine(C) to Guanine (G). The genome is the perplexing key in instructing cells to do theirRead MoreHow The Firm Strategy Affect The Emergence Of The Genomic Industry?1489 Words   |  6 Pagesanalysis of an individual’s genome. The industry can create a new avenue of approach in which it may profit through the production of tailored products and insights through the study of individual genome. This will also allow for the development of new technology and growth. Because of the necessity of a great quantity of diverse phenotypic and genomic data, this industry firm strategy will also consider genome databases and direct to consumer (DTC) genetic testing. Genome databases will give companiesRead MoreBiological Networks And The Biomedical And Genomic Fields962 Words   |  4 Pagesare ENCODE (Encyclopedia of DNA Elements) and TCGA (The Cancer Genome Atlas). The ENCODE project14, 15 was launched to identify all functional elements in the human genome - regions of transcription, transcription factor association, chromatin structure and histone modification. The ENCODE project has generated more than 6000 genomic datasets from ChIP-seq, RNA-seq, DNase-seq, shRNA knockdown followed by RNA-seq (The ENCODE Project Consortium, 2015). The pilot phase of the ENCODE project involved 440Read MoreThe Encyclopedia Of Dna Elements2407 Words   |  10 Pages The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential output from genomesRead MoreGenome Decoding: A Review of Three Articles1724 Words   |  7 Pagesthen states the reason why this newspaper gave a better version of the covered story among others based on the tendency (context), the information giving, and the supported arguments that this newspaper have. Genome Decoding: A review of three articles on the subject Introduction Genome Decoding is one of the most recent tantalizing scientific discoveries that have recently appeared in the news. Scientists have discovered that the 20,000 genes that do not code for proteins (and were, thereforeRead MoreAnnotated Bibliography On The Rna Profiling1999 Words   |  8 Pagesthe genome functions also. These observation are taken up together to form and define the functions and description related to genes (Bell, 2004). This observation tells about the range of expression and localization. As the technology is been improving day by day for the RNA profiling and the type of isolation made by the cells , the number of RNA has grown and has increase the biological function in an fast and immediate rate. The ENCODE project also known as the Encyclopedia of DNA element projectRead MoreCharacteristics Of The Functional Area Of Human Genome2127 Words   |  9 Pagessegment of human genome is formed of protein sequences while some of the non coded DNA indicates biologica l functions. Along with the coding of genomes, they are also consisted of sequence which is transcript into RNA like tRNA, rRNA .New challenges of these sequences in the non protein are most prevalent. They are known to identify the functional area in the human genome which is studied by (ENCODE) project. The characteristics which are acting upon the regulatory variations amongst the human beingsRead MoreAnnotated Bibliography On The Landscape Of Transcription2715 Words   |  11 PagesLANDSCAPE OF TRANSCRIPTION IN HUMAN CELLS INTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and geneRead MoreThe Encyclopedia Of Dna Elements2709 Words   |  11 PagesINTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential outputRead MoreSilico Characterization Of The Association Between Rs12670798 And Ldl Cholesterol2868 Words   |  12 PagesIntroduction Complex diseases are caused by multiple genetic and environmental factors working in combination with each other and thus, it is difficult to characterise the contribution of any one factor to the disease1. However, the widespread adoption of genome-wide association studies (GWAS) has greatly accelerated the rate at which these factors are discovered and characterised. These studies genotype individuals with different phenotypes (for example, those who are affected or unaffected by a complex