Sunday, May 17, 2020

The Human Genome Project And Encyclopedia Of Dna Elements

Understanding our life as we know it must start at the basics with our own DNA. DNA is the building blocks for all life, so to understand life we must analyze the mechanism of genetics. Projects like the Human Genome project and Encyclopedia of DNA elements (ENCODE) analyzes DNA to give society an interpretation of what the building code is and means. Our genetic code holds coding and non-coding sequences, at first researchers focused solely on coding DNA for it carried the function and means to life. The other non-coding was for years considered to be junk but in this review it will be highlighted by the example of Transposable elements that this so called useless DNA holds many secrets and keys to life. It is now recognized that genomic changes are influenced by transposable elements which has changed the way it is thought how genomes evolve and work. DNA Introduction Deoxyribonucleic acid, the building blocks for about all living creatures on Earth. Almost every cell in the human body shares the same DNA. Since DNA is practically the blueprint for living organisms, understanding the blueprint is crucial to a better understanding of the phenomena of our own bodies and the relationship between genetic variation and disease risk hopefully leading to the cure of many diseases, the prevention of harmful mutations, and possibly an explanation to our creation. This DNA is all the information for one’s body and is stored as a code with 4 chemical bases. As seen in theShow MoreRelatedEssay on The Human Genome Project1437 Words   |  6 Pagesdeeply in our body is the complex biological story. The Human Genome Project is the exploration of this intricate yet crucial storyline. The Genome is a complete set of genes that make up an organism. Genes are made up of DNA (deoxynucleic acid) which subsequently is made up of long paired strands. These paire d strands attach in a specific manner, for example, Adenine (A) attaches itself to Thymine (T) and Cytosine(C) to Guanine (G). The genome is the perplexing key in instructing cells to do theirRead MoreHow The Firm Strategy Affect The Emergence Of The Genomic Industry?1489 Words   |  6 Pagesanalysis of an individual’s genome. The industry can create a new avenue of approach in which it may profit through the production of tailored products and insights through the study of individual genome. This will also allow for the development of new technology and growth. Because of the necessity of a great quantity of diverse phenotypic and genomic data, this industry firm strategy will also consider genome databases and direct to consumer (DTC) genetic testing. Genome databases will give companiesRead MoreBiological Networks And The Biomedical And Genomic Fields962 Words   |  4 Pagesare ENCODE (Encyclopedia of DNA Elements) and TCGA (The Cancer Genome Atlas). The ENCODE project14, 15 was launched to identify all functional elements in the human genome - regions of transcription, transcription factor association, chromatin structure and histone modification. The ENCODE project has generated more than 6000 genomic datasets from ChIP-seq, RNA-seq, DNase-seq, shRNA knockdown followed by RNA-seq (The ENCODE Project Consortium, 2015). The pilot phase of the ENCODE project involved 440Read MoreThe Encyclopedia Of Dna Elements2407 Words   |  10 Pages The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential output from genomesRead MoreGenome Decoding: A Review of Three Articles1724 Words   |  7 Pagesthen states the reason why this newspaper gave a better version of the covered story among others based on the tendency (context), the information giving, and the supported arguments that this newspaper have. Genome Decoding: A review of three articles on the subject Introduction Genome Decoding is one of the most recent tantalizing scientific discoveries that have recently appeared in the news. Scientists have discovered that the 20,000 genes that do not code for proteins (and were, thereforeRead MoreAnnotated Bibliography On The Rna Profiling1999 Words   |  8 Pagesthe genome functions also. These observation are taken up together to form and define the functions and description related to genes (Bell, 2004). This observation tells about the range of expression and localization. As the technology is been improving day by day for the RNA profiling and the type of isolation made by the cells , the number of RNA has grown and has increase the biological function in an fast and immediate rate. The ENCODE project also known as the Encyclopedia of DNA element projectRead MoreCharacteristics Of The Functional Area Of Human Genome2127 Words   |  9 Pagessegment of human genome is formed of protein sequences while some of the non coded DNA indicates biologica l functions. Along with the coding of genomes, they are also consisted of sequence which is transcript into RNA like tRNA, rRNA .New challenges of these sequences in the non protein are most prevalent. They are known to identify the functional area in the human genome which is studied by (ENCODE) project. The characteristics which are acting upon the regulatory variations amongst the human beingsRead MoreAnnotated Bibliography On The Landscape Of Transcription2715 Words   |  11 PagesLANDSCAPE OF TRANSCRIPTION IN HUMAN CELLS INTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and geneRead MoreThe Encyclopedia Of Dna Elements2709 Words   |  11 PagesINTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential outputRead MoreSilico Characterization Of The Association Between Rs12670798 And Ldl Cholesterol2868 Words   |  12 PagesIntroduction Complex diseases are caused by multiple genetic and environmental factors working in combination with each other and thus, it is difficult to characterise the contribution of any one factor to the disease1. However, the widespread adoption of genome-wide association studies (GWAS) has greatly accelerated the rate at which these factors are discovered and characterised. These studies genotype individuals with different phenotypes (for example, those who are affected or unaffected by a complex

The Human Genome Project And Encyclopedia Of Dna Elements

Understanding our life as we know it must start at the basics with our own DNA. DNA is the building blocks for all life, so to understand life we must analyze the mechanism of genetics. Projects like the Human Genome project and Encyclopedia of DNA elements (ENCODE) analyzes DNA to give society an interpretation of what the building code is and means. Our genetic code holds coding and non-coding sequences, at first researchers focused solely on coding DNA for it carried the function and means to life. The other non-coding was for years considered to be junk but in this review it will be highlighted by the example of Transposable elements that this so called useless DNA holds many secrets and keys to life. It is now recognized that genomic changes are influenced by transposable elements which has changed the way it is thought how genomes evolve and work. DNA Introduction Deoxyribonucleic acid, the building blocks for about all living creatures on Earth. Almost every cell in the human body shares the same DNA. Since DNA is practically the blueprint for living organisms, understanding the blueprint is crucial to a better understanding of the phenomena of our own bodies and the relationship between genetic variation and disease risk hopefully leading to the cure of many diseases, the prevention of harmful mutations, and possibly an explanation to our creation. This DNA is all the information for one’s body and is stored as a code with 4 chemical bases. As seen in theShow MoreRelatedEssay on The Human Genome Project1437 Words   |  6 Pagesdeeply in our body is the complex biological story. The Human Genome Project is the exploration of this intricate yet crucial storyline. The Genome is a complete set of genes that make up an organism. Genes are made up of DNA (deoxynucleic acid) which subsequently is made up of long paired strands. These paire d strands attach in a specific manner, for example, Adenine (A) attaches itself to Thymine (T) and Cytosine(C) to Guanine (G). The genome is the perplexing key in instructing cells to do theirRead MoreHow The Firm Strategy Affect The Emergence Of The Genomic Industry?1489 Words   |  6 Pagesanalysis of an individual’s genome. The industry can create a new avenue of approach in which it may profit through the production of tailored products and insights through the study of individual genome. This will also allow for the development of new technology and growth. Because of the necessity of a great quantity of diverse phenotypic and genomic data, this industry firm strategy will also consider genome databases and direct to consumer (DTC) genetic testing. Genome databases will give companiesRead MoreBiological Networks And The Biomedical And Genomic Fields962 Words   |  4 Pagesare ENCODE (Encyclopedia of DNA Elements) and TCGA (The Cancer Genome Atlas). The ENCODE project14, 15 was launched to identify all functional elements in the human genome - regions of transcription, transcription factor association, chromatin structure and histone modification. The ENCODE project has generated more than 6000 genomic datasets from ChIP-seq, RNA-seq, DNase-seq, shRNA knockdown followed by RNA-seq (The ENCODE Project Consortium, 2015). The pilot phase of the ENCODE project involved 440Read MoreThe Encyclopedia Of Dna Elements2407 Words   |  10 Pages The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential output from genomesRead MoreGenome Decoding: A Review of Three Articles1724 Words   |  7 Pagesthen states the reason why this newspaper gave a better version of the covered story among others based on the tendency (context), the information giving, and the supported arguments that this newspaper have. Genome Decoding: A review of three articles on the subject Introduction Genome Decoding is one of the most recent tantalizing scientific discoveries that have recently appeared in the news. Scientists have discovered that the 20,000 genes that do not code for proteins (and were, thereforeRead MoreAnnotated Bibliography On The Rna Profiling1999 Words   |  8 Pagesthe genome functions also. These observation are taken up together to form and define the functions and description related to genes (Bell, 2004). This observation tells about the range of expression and localization. As the technology is been improving day by day for the RNA profiling and the type of isolation made by the cells , the number of RNA has grown and has increase the biological function in an fast and immediate rate. The ENCODE project also known as the Encyclopedia of DNA element projectRead MoreCharacteristics Of The Functional Area Of Human Genome2127 Words   |  9 Pagessegment of human genome is formed of protein sequences while some of the non coded DNA indicates biologica l functions. Along with the coding of genomes, they are also consisted of sequence which is transcript into RNA like tRNA, rRNA .New challenges of these sequences in the non protein are most prevalent. They are known to identify the functional area in the human genome which is studied by (ENCODE) project. The characteristics which are acting upon the regulatory variations amongst the human beingsRead MoreAnnotated Bibliography On The Landscape Of Transcription2715 Words   |  11 PagesLANDSCAPE OF TRANSCRIPTION IN HUMAN CELLS INTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and geneRead MoreThe Encyclopedia Of Dna Elements2709 Words   |  11 PagesINTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential outputRead MoreSilico Characterization Of The Association Between Rs12670798 And Ldl Cholesterol2868 Words   |  12 PagesIntroduction Complex diseases are caused by multiple genetic and environmental factors working in combination with each other and thus, it is difficult to characterise the contribution of any one factor to the disease1. However, the widespread adoption of genome-wide association studies (GWAS) has greatly accelerated the rate at which these factors are discovered and characterised. These studies genotype individuals with different phenotypes (for example, those who are affected or unaffected by a complex

The Human Genome Project And Encyclopedia Of Dna Elements

Understanding our life as we know it must start at the basics with our own DNA. DNA is the building blocks for all life, so to understand life we must analyze the mechanism of genetics. Projects like the Human Genome project and Encyclopedia of DNA elements (ENCODE) analyzes DNA to give society an interpretation of what the building code is and means. Our genetic code holds coding and non-coding sequences, at first researchers focused solely on coding DNA for it carried the function and means to life. The other non-coding was for years considered to be junk but in this review it will be highlighted by the example of Transposable elements that this so called useless DNA holds many secrets and keys to life. It is now recognized that genomic changes are influenced by transposable elements which has changed the way it is thought how genomes evolve and work. DNA Introduction Deoxyribonucleic acid, the building blocks for about all living creatures on Earth. Almost every cell in the human body shares the same DNA. Since DNA is practically the blueprint for living organisms, understanding the blueprint is crucial to a better understanding of the phenomena of our own bodies and the relationship between genetic variation and disease risk hopefully leading to the cure of many diseases, the prevention of harmful mutations, and possibly an explanation to our creation. This DNA is all the information for one’s body and is stored as a code with 4 chemical bases. As seen in theShow MoreRelatedEssay on The Human Genome Project1437 Words   |  6 Pagesdeeply in our body is the complex biological story. The Human Genome Project is the exploration of this intricate yet crucial storyline. The Genome is a complete set of genes that make up an organism. Genes are made up of DNA (deoxynucleic acid) which subsequently is made up of long paired strands. These paire d strands attach in a specific manner, for example, Adenine (A) attaches itself to Thymine (T) and Cytosine(C) to Guanine (G). The genome is the perplexing key in instructing cells to do theirRead MoreHow The Firm Strategy Affect The Emergence Of The Genomic Industry?1489 Words   |  6 Pagesanalysis of an individual’s genome. The industry can create a new avenue of approach in which it may profit through the production of tailored products and insights through the study of individual genome. This will also allow for the development of new technology and growth. Because of the necessity of a great quantity of diverse phenotypic and genomic data, this industry firm strategy will also consider genome databases and direct to consumer (DTC) genetic testing. Genome databases will give companiesRead MoreBiological Networks And The Biomedical And Genomic Fields962 Words   |  4 Pagesare ENCODE (Encyclopedia of DNA Elements) and TCGA (The Cancer Genome Atlas). The ENCODE project14, 15 was launched to identify all functional elements in the human genome - regions of transcription, transcription factor association, chromatin structure and histone modification. The ENCODE project has generated more than 6000 genomic datasets from ChIP-seq, RNA-seq, DNase-seq, shRNA knockdown followed by RNA-seq (The ENCODE Project Consortium, 2015). The pilot phase of the ENCODE project involved 440Read MoreThe Encyclopedia Of Dna Elements2407 Words   |  10 Pages The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential output from genomesRead MoreGenome Decoding: A Review of Three Articles1724 Words   |  7 Pagesthen states the reason why this newspaper gave a better version of the covered story among others based on the tendency (context), the information giving, and the supported arguments that this newspaper have. Genome Decoding: A review of three articles on the subject Introduction Genome Decoding is one of the most recent tantalizing scientific discoveries that have recently appeared in the news. Scientists have discovered that the 20,000 genes that do not code for proteins (and were, thereforeRead MoreAnnotated Bibliography On The Rna Profiling1999 Words   |  8 Pagesthe genome functions also. These observation are taken up together to form and define the functions and description related to genes (Bell, 2004). This observation tells about the range of expression and localization. As the technology is been improving day by day for the RNA profiling and the type of isolation made by the cells , the number of RNA has grown and has increase the biological function in an fast and immediate rate. The ENCODE project also known as the Encyclopedia of DNA element projectRead MoreCharacteristics Of The Functional Area Of Human Genome2127 Words   |  9 Pagessegment of human genome is formed of protein sequences while some of the non coded DNA indicates biologica l functions. Along with the coding of genomes, they are also consisted of sequence which is transcript into RNA like tRNA, rRNA .New challenges of these sequences in the non protein are most prevalent. They are known to identify the functional area in the human genome which is studied by (ENCODE) project. The characteristics which are acting upon the regulatory variations amongst the human beingsRead MoreAnnotated Bibliography On The Landscape Of Transcription2715 Words   |  11 PagesLANDSCAPE OF TRANSCRIPTION IN HUMAN CELLS INTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and geneRead MoreThe Encyclopedia Of Dna Elements2709 Words   |  11 PagesINTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential outputRead MoreSilico Characterization Of The Association Between Rs12670798 And Ldl Cholesterol2868 Words   |  12 PagesIntroduction Complex diseases are caused by multiple genetic and environmental factors working in combination with each other and thus, it is difficult to characterise the contribution of any one factor to the disease1. However, the widespread adoption of genome-wide association studies (GWAS) has greatly accelerated the rate at which these factors are discovered and characterised. These studies genotype individuals with different phenotypes (for example, those who are affected or unaffected by a complex

The Human Genome Project And Encyclopedia Of Dna Elements

Understanding our life as we know it must start at the basics with our own DNA. DNA is the building blocks for all life, so to understand life we must analyze the mechanism of genetics. Projects like the Human Genome project and Encyclopedia of DNA elements (ENCODE) analyzes DNA to give society an interpretation of what the building code is and means. Our genetic code holds coding and non-coding sequences, at first researchers focused solely on coding DNA for it carried the function and means to life. The other non-coding was for years considered to be junk but in this review it will be highlighted by the example of Transposable elements that this so called useless DNA holds many secrets and keys to life. It is now recognized that genomic changes are influenced by transposable elements which has changed the way it is thought how genomes evolve and work. DNA Introduction Deoxyribonucleic acid, the building blocks for about all living creatures on Earth. Almost every cell in the human body shares the same DNA. Since DNA is practically the blueprint for living organisms, understanding the blueprint is crucial to a better understanding of the phenomena of our own bodies and the relationship between genetic variation and disease risk hopefully leading to the cure of many diseases, the prevention of harmful mutations, and possibly an explanation to our creation. This DNA is all the information for one’s body and is stored as a code with 4 chemical bases. As seen in theShow MoreRelatedEssay on The Human Genome Project1437 Words   |  6 Pagesdeeply in our body is the complex biological story. The Human Genome Project is the exploration of this intricate yet crucial storyline. The Genome is a complete set of genes that make up an organism. Genes are made up of DNA (deoxynucleic acid) which subsequently is made up of long paired strands. These paire d strands attach in a specific manner, for example, Adenine (A) attaches itself to Thymine (T) and Cytosine(C) to Guanine (G). The genome is the perplexing key in instructing cells to do theirRead MoreHow The Firm Strategy Affect The Emergence Of The Genomic Industry?1489 Words   |  6 Pagesanalysis of an individual’s genome. The industry can create a new avenue of approach in which it may profit through the production of tailored products and insights through the study of individual genome. This will also allow for the development of new technology and growth. Because of the necessity of a great quantity of diverse phenotypic and genomic data, this industry firm strategy will also consider genome databases and direct to consumer (DTC) genetic testing. Genome databases will give companiesRead MoreBiological Networks And The Biomedical And Genomic Fields962 Words   |  4 Pagesare ENCODE (Encyclopedia of DNA Elements) and TCGA (The Cancer Genome Atlas). The ENCODE project14, 15 was launched to identify all functional elements in the human genome - regions of transcription, transcription factor association, chromatin structure and histone modification. The ENCODE project has generated more than 6000 genomic datasets from ChIP-seq, RNA-seq, DNase-seq, shRNA knockdown followed by RNA-seq (The ENCODE Project Consortium, 2015). The pilot phase of the ENCODE project involved 440Read MoreThe Encyclopedia Of Dna Elements2407 Words   |  10 Pages The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential output from genomesRead MoreGenome Decoding: A Review of Three Articles1724 Words   |  7 Pagesthen states the reason why this newspaper gave a better version of the covered story among others based on the tendency (context), the information giving, and the supported arguments that this newspaper have. Genome Decoding: A review of three articles on the subject Introduction Genome Decoding is one of the most recent tantalizing scientific discoveries that have recently appeared in the news. Scientists have discovered that the 20,000 genes that do not code for proteins (and were, thereforeRead MoreAnnotated Bibliography On The Rna Profiling1999 Words   |  8 Pagesthe genome functions also. These observation are taken up together to form and define the functions and description related to genes (Bell, 2004). This observation tells about the range of expression and localization. As the technology is been improving day by day for the RNA profiling and the type of isolation made by the cells , the number of RNA has grown and has increase the biological function in an fast and immediate rate. The ENCODE project also known as the Encyclopedia of DNA element projectRead MoreCharacteristics Of The Functional Area Of Human Genome2127 Words   |  9 Pagessegment of human genome is formed of protein sequences while some of the non coded DNA indicates biologica l functions. Along with the coding of genomes, they are also consisted of sequence which is transcript into RNA like tRNA, rRNA .New challenges of these sequences in the non protein are most prevalent. They are known to identify the functional area in the human genome which is studied by (ENCODE) project. The characteristics which are acting upon the regulatory variations amongst the human beingsRead MoreAnnotated Bibliography On The Landscape Of Transcription2715 Words   |  11 PagesLANDSCAPE OF TRANSCRIPTION IN HUMAN CELLS INTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and geneRead MoreThe Encyclopedia Of Dna Elements2709 Words   |  11 PagesINTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential outputRead MoreSilico Characterization Of The Association Between Rs12670798 And Ldl Cholesterol2868 Words   |  12 PagesIntroduction Complex diseases are caused by multiple genetic and environmental factors working in combination with each other and thus, it is difficult to characterise the contribution of any one factor to the disease1. However, the widespread adoption of genome-wide association studies (GWAS) has greatly accelerated the rate at which these factors are discovered and characterised. These studies genotype individuals with different phenotypes (for example, those who are affected or unaffected by a complex

The Human Genome Project And Encyclopedia Of Dna Elements

Understanding our life as we know it must start at the basics with our own DNA. DNA is the building blocks for all life, so to understand life we must analyze the mechanism of genetics. Projects like the Human Genome project and Encyclopedia of DNA elements (ENCODE) analyzes DNA to give society an interpretation of what the building code is and means. Our genetic code holds coding and non-coding sequences, at first researchers focused solely on coding DNA for it carried the function and means to life. The other non-coding was for years considered to be junk but in this review it will be highlighted by the example of Transposable elements that this so called useless DNA holds many secrets and keys to life. It is now recognized that genomic changes are influenced by transposable elements which has changed the way it is thought how genomes evolve and work. DNA Introduction Deoxyribonucleic acid, the building blocks for about all living creatures on Earth. Almost every cell in the human body shares the same DNA. Since DNA is practically the blueprint for living organisms, understanding the blueprint is crucial to a better understanding of the phenomena of our own bodies and the relationship between genetic variation and disease risk hopefully leading to the cure of many diseases, the prevention of harmful mutations, and possibly an explanation to our creation. This DNA is all the information for one’s body and is stored as a code with 4 chemical bases. As seen in theShow MoreRelatedEssay on The Human Genome Project1437 Words   |  6 Pagesdeeply in our body is the complex biological story. The Human Genome Project is the exploration of this intricate yet crucial storyline. The Genome is a complete set of genes that make up an organism. Genes are made up of DNA (deoxynucleic acid) which subsequently is made up of long paired strands. These paire d strands attach in a specific manner, for example, Adenine (A) attaches itself to Thymine (T) and Cytosine(C) to Guanine (G). The genome is the perplexing key in instructing cells to do theirRead MoreHow The Firm Strategy Affect The Emergence Of The Genomic Industry?1489 Words   |  6 Pagesanalysis of an individual’s genome. The industry can create a new avenue of approach in which it may profit through the production of tailored products and insights through the study of individual genome. This will also allow for the development of new technology and growth. Because of the necessity of a great quantity of diverse phenotypic and genomic data, this industry firm strategy will also consider genome databases and direct to consumer (DTC) genetic testing. Genome databases will give companiesRead MoreBiological Networks And The Biomedical And Genomic Fields962 Words   |  4 Pagesare ENCODE (Encyclopedia of DNA Elements) and TCGA (The Cancer Genome Atlas). The ENCODE project14, 15 was launched to identify all functional elements in the human genome - regions of transcription, transcription factor association, chromatin structure and histone modification. The ENCODE project has generated more than 6000 genomic datasets from ChIP-seq, RNA-seq, DNase-seq, shRNA knockdown followed by RNA-seq (The ENCODE Project Consortium, 2015). The pilot phase of the ENCODE project involved 440Read MoreThe Encyclopedia Of Dna Elements2407 Words   |  10 Pages The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential output from genomesRead MoreGenome Decoding: A Review of Three Articles1724 Words   |  7 Pagesthen states the reason why this newspaper gave a better version of the covered story among others based on the tendency (context), the information giving, and the supported arguments that this newspaper have. Genome Decoding: A review of three articles on the subject Introduction Genome Decoding is one of the most recent tantalizing scientific discoveries that have recently appeared in the news. Scientists have discovered that the 20,000 genes that do not code for proteins (and were, thereforeRead MoreAnnotated Bibliography On The Rna Profiling1999 Words   |  8 Pagesthe genome functions also. These observation are taken up together to form and define the functions and description related to genes (Bell, 2004). This observation tells about the range of expression and localization. As the technology is been improving day by day for the RNA profiling and the type of isolation made by the cells , the number of RNA has grown and has increase the biological function in an fast and immediate rate. The ENCODE project also known as the Encyclopedia of DNA element projectRead MoreCharacteristics Of The Functional Area Of Human Genome2127 Words   |  9 Pagessegment of human genome is formed of protein sequences while some of the non coded DNA indicates biologica l functions. Along with the coding of genomes, they are also consisted of sequence which is transcript into RNA like tRNA, rRNA .New challenges of these sequences in the non protein are most prevalent. They are known to identify the functional area in the human genome which is studied by (ENCODE) project. The characteristics which are acting upon the regulatory variations amongst the human beingsRead MoreAnnotated Bibliography On The Landscape Of Transcription2715 Words   |  11 PagesLANDSCAPE OF TRANSCRIPTION IN HUMAN CELLS INTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and geneRead MoreThe Encyclopedia Of Dna Elements2709 Words   |  11 PagesINTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential outputRead MoreSilico Characterization Of The Association Between Rs12670798 And Ldl Cholesterol2868 Words   |  12 PagesIntroduction Complex diseases are caused by multiple genetic and environmental factors working in combination with each other and thus, it is difficult to characterise the contribution of any one factor to the disease1. However, the widespread adoption of genome-wide association studies (GWAS) has greatly accelerated the rate at which these factors are discovered and characterised. These studies genotype individuals with different phenotypes (for example, those who are affected or unaffected by a complex

The Human Genome Project And Encyclopedia Of Dna Elements

Understanding our life as we know it must start at the basics with our own DNA. DNA is the building blocks for all life, so to understand life we must analyze the mechanism of genetics. Projects like the Human Genome project and Encyclopedia of DNA elements (ENCODE) analyzes DNA to give society an interpretation of what the building code is and means. Our genetic code holds coding and non-coding sequences, at first researchers focused solely on coding DNA for it carried the function and means to life. The other non-coding was for years considered to be junk but in this review it will be highlighted by the example of Transposable elements that this so called useless DNA holds many secrets and keys to life. It is now recognized that genomic changes are influenced by transposable elements which has changed the way it is thought how genomes evolve and work. DNA Introduction Deoxyribonucleic acid, the building blocks for about all living creatures on Earth. Almost every cell in the human body shares the same DNA. Since DNA is practically the blueprint for living organisms, understanding the blueprint is crucial to a better understanding of the phenomena of our own bodies and the relationship between genetic variation and disease risk hopefully leading to the cure of many diseases, the prevention of harmful mutations, and possibly an explanation to our creation. This DNA is all the information for one’s body and is stored as a code with 4 chemical bases. As seen in theShow MoreRelatedEssay on The Human Genome Project1437 Words   |  6 Pagesdeeply in our body is the complex biological story. The Human Genome Project is the exploration of this intricate yet crucial storyline. The Genome is a complete set of genes that make up an organism. Genes are made up of DNA (deoxynucleic acid) which subsequently is made up of long paired strands. These paire d strands attach in a specific manner, for example, Adenine (A) attaches itself to Thymine (T) and Cytosine(C) to Guanine (G). The genome is the perplexing key in instructing cells to do theirRead MoreHow The Firm Strategy Affect The Emergence Of The Genomic Industry?1489 Words   |  6 Pagesanalysis of an individual’s genome. The industry can create a new avenue of approach in which it may profit through the production of tailored products and insights through the study of individual genome. This will also allow for the development of new technology and growth. Because of the necessity of a great quantity of diverse phenotypic and genomic data, this industry firm strategy will also consider genome databases and direct to consumer (DTC) genetic testing. Genome databases will give companiesRead MoreBiological Networks And The Biomedical And Genomic Fields962 Words   |  4 Pagesare ENCODE (Encyclopedia of DNA Elements) and TCGA (The Cancer Genome Atlas). The ENCODE project14, 15 was launched to identify all functional elements in the human genome - regions of transcription, transcription factor association, chromatin structure and histone modification. The ENCODE project has generated more than 6000 genomic datasets from ChIP-seq, RNA-seq, DNase-seq, shRNA knockdown followed by RNA-seq (The ENCODE Project Consortium, 2015). The pilot phase of the ENCODE project involved 440Read MoreThe Encyclopedia Of Dna Elements2407 Words   |  10 Pages The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential output from genomesRead MoreGenome Decoding: A Review of Three Articles1724 Words   |  7 Pagesthen states the reason why this newspaper gave a better version of the covered story among others based on the tendency (context), the information giving, and the supported arguments that this newspaper have. Genome Decoding: A review of three articles on the subject Introduction Genome Decoding is one of the most recent tantalizing scientific discoveries that have recently appeared in the news. Scientists have discovered that the 20,000 genes that do not code for proteins (and were, thereforeRead MoreAnnotated Bibliography On The Rna Profiling1999 Words   |  8 Pagesthe genome functions also. These observation are taken up together to form and define the functions and description related to genes (Bell, 2004). This observation tells about the range of expression and localization. As the technology is been improving day by day for the RNA profiling and the type of isolation made by the cells , the number of RNA has grown and has increase the biological function in an fast and immediate rate. The ENCODE project also known as the Encyclopedia of DNA element projectRead MoreCharacteristics Of The Functional Area Of Human Genome2127 Words   |  9 Pagessegment of human genome is formed of protein sequences while some of the non coded DNA indicates biologica l functions. Along with the coding of genomes, they are also consisted of sequence which is transcript into RNA like tRNA, rRNA .New challenges of these sequences in the non protein are most prevalent. They are known to identify the functional area in the human genome which is studied by (ENCODE) project. The characteristics which are acting upon the regulatory variations amongst the human beingsRead MoreAnnotated Bibliography On The Landscape Of Transcription2715 Words   |  11 PagesLANDSCAPE OF TRANSCRIPTION IN HUMAN CELLS INTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and geneRead MoreThe Encyclopedia Of Dna Elements2709 Words   |  11 PagesINTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential outputRead MoreSilico Characterization Of The Association Between Rs12670798 And Ldl Cholesterol2868 Words   |  12 PagesIntroduction Complex diseases are caused by multiple genetic and environmental factors working in combination with each other and thus, it is difficult to characterise the contribution of any one factor to the disease1. However, the widespread adoption of genome-wide association studies (GWAS) has greatly accelerated the rate at which these factors are discovered and characterised. These studies genotype individuals with different phenotypes (for example, those who are affected or unaffected by a complex

The Human Genome Project And Encyclopedia Of Dna Elements

Understanding our life as we know it must start at the basics with our own DNA. DNA is the building blocks for all life, so to understand life we must analyze the mechanism of genetics. Projects like the Human Genome project and Encyclopedia of DNA elements (ENCODE) analyzes DNA to give society an interpretation of what the building code is and means. Our genetic code holds coding and non-coding sequences, at first researchers focused solely on coding DNA for it carried the function and means to life. The other non-coding was for years considered to be junk but in this review it will be highlighted by the example of Transposable elements that this so called useless DNA holds many secrets and keys to life. It is now recognized that genomic changes are influenced by transposable elements which has changed the way it is thought how genomes evolve and work. DNA Introduction Deoxyribonucleic acid, the building blocks for about all living creatures on Earth. Almost every cell in the human body shares the same DNA. Since DNA is practically the blueprint for living organisms, understanding the blueprint is crucial to a better understanding of the phenomena of our own bodies and the relationship between genetic variation and disease risk hopefully leading to the cure of many diseases, the prevention of harmful mutations, and possibly an explanation to our creation. This DNA is all the information for one’s body and is stored as a code with 4 chemical bases. As seen in theShow MoreRelatedEssay on The Human Genome Project1437 Words   |  6 Pagesdeeply in our body is the complex biological story. The Human Genome Project is the exploration of this intricate yet crucial storyline. The Genome is a complete set of genes that make up an organism. Genes are made up of DNA (deoxynucleic acid) which subsequently is made up of long paired strands. These paire d strands attach in a specific manner, for example, Adenine (A) attaches itself to Thymine (T) and Cytosine(C) to Guanine (G). The genome is the perplexing key in instructing cells to do theirRead MoreHow The Firm Strategy Affect The Emergence Of The Genomic Industry?1489 Words   |  6 Pagesanalysis of an individual’s genome. The industry can create a new avenue of approach in which it may profit through the production of tailored products and insights through the study of individual genome. This will also allow for the development of new technology and growth. Because of the necessity of a great quantity of diverse phenotypic and genomic data, this industry firm strategy will also consider genome databases and direct to consumer (DTC) genetic testing. Genome databases will give companiesRead MoreBiological Networks And The Biomedical And Genomic Fields962 Words   |  4 Pagesare ENCODE (Encyclopedia of DNA Elements) and TCGA (The Cancer Genome Atlas). The ENCODE project14, 15 was launched to identify all functional elements in the human genome - regions of transcription, transcription factor association, chromatin structure and histone modification. The ENCODE project has generated more than 6000 genomic datasets from ChIP-seq, RNA-seq, DNase-seq, shRNA knockdown followed by RNA-seq (The ENCODE Project Consortium, 2015). The pilot phase of the ENCODE project involved 440Read MoreThe Encyclopedia Of Dna Elements2407 Words   |  10 Pages The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential output from genomesRead MoreGenome Decoding: A Review of Three Articles1724 Words   |  7 Pagesthen states the reason why this newspaper gave a better version of the covered story among others based on the tendency (context), the information giving, and the supported arguments that this newspaper have. Genome Decoding: A review of three articles on the subject Introduction Genome Decoding is one of the most recent tantalizing scientific discoveries that have recently appeared in the news. Scientists have discovered that the 20,000 genes that do not code for proteins (and were, thereforeRead MoreAnnotated Bibliography On The Rna Profiling1999 Words   |  8 Pagesthe genome functions also. These observation are taken up together to form and define the functions and description related to genes (Bell, 2004). This observation tells about the range of expression and localization. As the technology is been improving day by day for the RNA profiling and the type of isolation made by the cells , the number of RNA has grown and has increase the biological function in an fast and immediate rate. The ENCODE project also known as the Encyclopedia of DNA element projectRead MoreCharacteristics Of The Functional Area Of Human Genome2127 Words   |  9 Pagessegment of human genome is formed of protein sequences while some of the non coded DNA indicates biologica l functions. Along with the coding of genomes, they are also consisted of sequence which is transcript into RNA like tRNA, rRNA .New challenges of these sequences in the non protein are most prevalent. They are known to identify the functional area in the human genome which is studied by (ENCODE) project. The characteristics which are acting upon the regulatory variations amongst the human beingsRead MoreAnnotated Bibliography On The Landscape Of Transcription2715 Words   |  11 PagesLANDSCAPE OF TRANSCRIPTION IN HUMAN CELLS INTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and geneRead MoreThe Encyclopedia Of Dna Elements2709 Words   |  11 PagesINTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential outputRead MoreSilico Characterization Of The Association Between Rs12670798 And Ldl Cholesterol2868 Words   |  12 PagesIntroduction Complex diseases are caused by multiple genetic and environmental factors working in combination with each other and thus, it is difficult to characterise the contribution of any one factor to the disease1. However, the widespread adoption of genome-wide association studies (GWAS) has greatly accelerated the rate at which these factors are discovered and characterised. These studies genotype individuals with different phenotypes (for example, those who are affected or unaffected by a complex

The Human Genome Project And Encyclopedia Of Dna Elements

Understanding our life as we know it must start at the basics with our own DNA. DNA is the building blocks for all life, so to understand life we must analyze the mechanism of genetics. Projects like the Human Genome project and Encyclopedia of DNA elements (ENCODE) analyzes DNA to give society an interpretation of what the building code is and means. Our genetic code holds coding and non-coding sequences, at first researchers focused solely on coding DNA for it carried the function and means to life. The other non-coding was for years considered to be junk but in this review it will be highlighted by the example of Transposable elements that this so called useless DNA holds many secrets and keys to life. It is now recognized that genomic changes are influenced by transposable elements which has changed the way it is thought how genomes evolve and work. DNA Introduction Deoxyribonucleic acid, the building blocks for about all living creatures on Earth. Almost every cell in the human body shares the same DNA. Since DNA is practically the blueprint for living organisms, understanding the blueprint is crucial to a better understanding of the phenomena of our own bodies and the relationship between genetic variation and disease risk hopefully leading to the cure of many diseases, the prevention of harmful mutations, and possibly an explanation to our creation. This DNA is all the information for one’s body and is stored as a code with 4 chemical bases. As seen in theShow MoreRelatedEssay on The Human Genome Project1437 Words   |  6 Pagesdeeply in our body is the complex biological story. The Human Genome Project is the exploration of this intricate yet crucial storyline. The Genome is a complete set of genes that make up an organism. Genes are made up of DNA (deoxynucleic acid) which subsequently is made up of long paired strands. These paire d strands attach in a specific manner, for example, Adenine (A) attaches itself to Thymine (T) and Cytosine(C) to Guanine (G). The genome is the perplexing key in instructing cells to do theirRead MoreHow The Firm Strategy Affect The Emergence Of The Genomic Industry?1489 Words   |  6 Pagesanalysis of an individual’s genome. The industry can create a new avenue of approach in which it may profit through the production of tailored products and insights through the study of individual genome. This will also allow for the development of new technology and growth. Because of the necessity of a great quantity of diverse phenotypic and genomic data, this industry firm strategy will also consider genome databases and direct to consumer (DTC) genetic testing. Genome databases will give companiesRead MoreBiological Networks And The Biomedical And Genomic Fields962 Words   |  4 Pagesare ENCODE (Encyclopedia of DNA Elements) and TCGA (The Cancer Genome Atlas). The ENCODE project14, 15 was launched to identify all functional elements in the human genome - regions of transcription, transcription factor association, chromatin structure and histone modification. The ENCODE project has generated more than 6000 genomic datasets from ChIP-seq, RNA-seq, DNase-seq, shRNA knockdown followed by RNA-seq (The ENCODE Project Consortium, 2015). The pilot phase of the ENCODE project involved 440Read MoreThe Encyclopedia Of Dna Elements2407 Words   |  10 Pages The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential output from genomesRead MoreGenome Decoding: A Review of Three Articles1724 Words   |  7 Pagesthen states the reason why this newspaper gave a better version of the covered story among others based on the tendency (context), the information giving, and the supported arguments that this newspaper have. Genome Decoding: A review of three articles on the subject Introduction Genome Decoding is one of the most recent tantalizing scientific discoveries that have recently appeared in the news. Scientists have discovered that the 20,000 genes that do not code for proteins (and were, thereforeRead MoreAnnotated Bibliography On The Rna Profiling1999 Words   |  8 Pagesthe genome functions also. These observation are taken up together to form and define the functions and description related to genes (Bell, 2004). This observation tells about the range of expression and localization. As the technology is been improving day by day for the RNA profiling and the type of isolation made by the cells , the number of RNA has grown and has increase the biological function in an fast and immediate rate. The ENCODE project also known as the Encyclopedia of DNA element projectRead MoreCharacteristics Of The Functional Area Of Human Genome2127 Words   |  9 Pagessegment of human genome is formed of protein sequences while some of the non coded DNA indicates biologica l functions. Along with the coding of genomes, they are also consisted of sequence which is transcript into RNA like tRNA, rRNA .New challenges of these sequences in the non protein are most prevalent. They are known to identify the functional area in the human genome which is studied by (ENCODE) project. The characteristics which are acting upon the regulatory variations amongst the human beingsRead MoreAnnotated Bibliography On The Landscape Of Transcription2715 Words   |  11 PagesLANDSCAPE OF TRANSCRIPTION IN HUMAN CELLS INTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and geneRead MoreThe Encyclopedia Of Dna Elements2709 Words   |  11 PagesINTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential outputRead MoreSilico Characterization Of The Association Between Rs12670798 And Ldl Cholesterol2868 Words   |  12 PagesIntroduction Complex diseases are caused by multiple genetic and environmental factors working in combination with each other and thus, it is difficult to characterise the contribution of any one factor to the disease1. However, the widespread adoption of genome-wide association studies (GWAS) has greatly accelerated the rate at which these factors are discovered and characterised. These studies genotype individuals with different phenotypes (for example, those who are affected or unaffected by a complex

The Human Genome Project And Encyclopedia Of Dna Elements

Understanding our life as we know it must start at the basics with our own DNA. DNA is the building blocks for all life, so to understand life we must analyze the mechanism of genetics. Projects like the Human Genome project and Encyclopedia of DNA elements (ENCODE) analyzes DNA to give society an interpretation of what the building code is and means. Our genetic code holds coding and non-coding sequences, at first researchers focused solely on coding DNA for it carried the function and means to life. The other non-coding was for years considered to be junk but in this review it will be highlighted by the example of Transposable elements that this so called useless DNA holds many secrets and keys to life. It is now recognized that genomic changes are influenced by transposable elements which has changed the way it is thought how genomes evolve and work. DNA Introduction Deoxyribonucleic acid, the building blocks for about all living creatures on Earth. Almost every cell in the human body shares the same DNA. Since DNA is practically the blueprint for living organisms, understanding the blueprint is crucial to a better understanding of the phenomena of our own bodies and the relationship between genetic variation and disease risk hopefully leading to the cure of many diseases, the prevention of harmful mutations, and possibly an explanation to our creation. This DNA is all the information for one’s body and is stored as a code with 4 chemical bases. As seen in theShow MoreRelatedEssay on The Human Genome Project1437 Words   |  6 Pagesdeeply in our body is the complex biological story. The Human Genome Project is the exploration of this intricate yet crucial storyline. The Genome is a complete set of genes that make up an organism. Genes are made up of DNA (deoxynucleic acid) which subsequently is made up of long paired strands. These paire d strands attach in a specific manner, for example, Adenine (A) attaches itself to Thymine (T) and Cytosine(C) to Guanine (G). The genome is the perplexing key in instructing cells to do theirRead MoreHow The Firm Strategy Affect The Emergence Of The Genomic Industry?1489 Words   |  6 Pagesanalysis of an individual’s genome. The industry can create a new avenue of approach in which it may profit through the production of tailored products and insights through the study of individual genome. This will also allow for the development of new technology and growth. Because of the necessity of a great quantity of diverse phenotypic and genomic data, this industry firm strategy will also consider genome databases and direct to consumer (DTC) genetic testing. Genome databases will give companiesRead MoreBiological Networks And The Biomedical And Genomic Fields962 Words   |  4 Pagesare ENCODE (Encyclopedia of DNA Elements) and TCGA (The Cancer Genome Atlas). The ENCODE project14, 15 was launched to identify all functional elements in the human genome - regions of transcription, transcription factor association, chromatin structure and histone modification. The ENCODE project has generated more than 6000 genomic datasets from ChIP-seq, RNA-seq, DNase-seq, shRNA knockdown followed by RNA-seq (The ENCODE Project Consortium, 2015). The pilot phase of the ENCODE project involved 440Read MoreThe Encyclopedia Of Dna Elements2407 Words   |  10 Pages The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential output from genomesRead MoreGenome Decoding: A Review of Three Articles1724 Words   |  7 Pagesthen states the reason why this newspaper gave a better version of the covered story among others based on the tendency (context), the information giving, and the supported arguments that this newspaper have. Genome Decoding: A review of three articles on the subject Introduction Genome Decoding is one of the most recent tantalizing scientific discoveries that have recently appeared in the news. Scientists have discovered that the 20,000 genes that do not code for proteins (and were, thereforeRead MoreAnnotated Bibliography On The Rna Profiling1999 Words   |  8 Pagesthe genome functions also. These observation are taken up together to form and define the functions and description related to genes (Bell, 2004). This observation tells about the range of expression and localization. As the technology is been improving day by day for the RNA profiling and the type of isolation made by the cells , the number of RNA has grown and has increase the biological function in an fast and immediate rate. The ENCODE project also known as the Encyclopedia of DNA element projectRead MoreCharacteristics Of The Functional Area Of Human Genome2127 Words   |  9 Pagessegment of human genome is formed of protein sequences while some of the non coded DNA indicates biologica l functions. Along with the coding of genomes, they are also consisted of sequence which is transcript into RNA like tRNA, rRNA .New challenges of these sequences in the non protein are most prevalent. They are known to identify the functional area in the human genome which is studied by (ENCODE) project. The characteristics which are acting upon the regulatory variations amongst the human beingsRead MoreAnnotated Bibliography On The Landscape Of Transcription2715 Words   |  11 PagesLANDSCAPE OF TRANSCRIPTION IN HUMAN CELLS INTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and geneRead MoreThe Encyclopedia Of Dna Elements2709 Words   |  11 PagesINTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential outputRead MoreSilico Characterization Of The Association Between Rs12670798 And Ldl Cholesterol2868 Words   |  12 PagesIntroduction Complex diseases are caused by multiple genetic and environmental factors working in combination with each other and thus, it is difficult to characterise the contribution of any one factor to the disease1. However, the widespread adoption of genome-wide association studies (GWAS) has greatly accelerated the rate at which these factors are discovered and characterised. These studies genotype individuals with different phenotypes (for example, those who are affected or unaffected by a complex

The Human Genome Project And Encyclopedia Of Dna Elements

Understanding our life as we know it must start at the basics with our own DNA. DNA is the building blocks for all life, so to understand life we must analyze the mechanism of genetics. Projects like the Human Genome project and Encyclopedia of DNA elements (ENCODE) analyzes DNA to give society an interpretation of what the building code is and means. Our genetic code holds coding and non-coding sequences, at first researchers focused solely on coding DNA for it carried the function and means to life. The other non-coding was for years considered to be junk but in this review it will be highlighted by the example of Transposable elements that this so called useless DNA holds many secrets and keys to life. It is now recognized that genomic changes are influenced by transposable elements which has changed the way it is thought how genomes evolve and work. DNA Introduction Deoxyribonucleic acid, the building blocks for about all living creatures on Earth. Almost every cell in the human body shares the same DNA. Since DNA is practically the blueprint for living organisms, understanding the blueprint is crucial to a better understanding of the phenomena of our own bodies and the relationship between genetic variation and disease risk hopefully leading to the cure of many diseases, the prevention of harmful mutations, and possibly an explanation to our creation. This DNA is all the information for one’s body and is stored as a code with 4 chemical bases. As seen in theShow MoreRelatedEssay on The Human Genome Project1437 Words   |  6 Pagesdeeply in our body is the complex biological story. The Human Genome Project is the exploration of this intricate yet crucial storyline. The Genome is a complete set of genes that make up an organism. Genes are made up of DNA (deoxynucleic acid) which subsequently is made up of long paired strands. These paire d strands attach in a specific manner, for example, Adenine (A) attaches itself to Thymine (T) and Cytosine(C) to Guanine (G). The genome is the perplexing key in instructing cells to do theirRead MoreHow The Firm Strategy Affect The Emergence Of The Genomic Industry?1489 Words   |  6 Pagesanalysis of an individual’s genome. The industry can create a new avenue of approach in which it may profit through the production of tailored products and insights through the study of individual genome. This will also allow for the development of new technology and growth. Because of the necessity of a great quantity of diverse phenotypic and genomic data, this industry firm strategy will also consider genome databases and direct to consumer (DTC) genetic testing. Genome databases will give companiesRead MoreBiological Networks And The Biomedical And Genomic Fields962 Words   |  4 Pagesare ENCODE (Encyclopedia of DNA Elements) and TCGA (The Cancer Genome Atlas). The ENCODE project14, 15 was launched to identify all functional elements in the human genome - regions of transcription, transcription factor association, chromatin structure and histone modification. The ENCODE project has generated more than 6000 genomic datasets from ChIP-seq, RNA-seq, DNase-seq, shRNA knockdown followed by RNA-seq (The ENCODE Project Consortium, 2015). The pilot phase of the ENCODE project involved 440Read MoreThe Encyclopedia Of Dna Elements2407 Words   |  10 Pages The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential output from genomesRead MoreGenome Decoding: A Review of Three Articles1724 Words   |  7 Pagesthen states the reason why this newspaper gave a better version of the covered story among others based on the tendency (context), the information giving, and the supported arguments that this newspaper have. Genome Decoding: A review of three articles on the subject Introduction Genome Decoding is one of the most recent tantalizing scientific discoveries that have recently appeared in the news. Scientists have discovered that the 20,000 genes that do not code for proteins (and were, thereforeRead MoreAnnotated Bibliography On The Rna Profiling1999 Words   |  8 Pagesthe genome functions also. These observation are taken up together to form and define the functions and description related to genes (Bell, 2004). This observation tells about the range of expression and localization. As the technology is been improving day by day for the RNA profiling and the type of isolation made by the cells , the number of RNA has grown and has increase the biological function in an fast and immediate rate. The ENCODE project also known as the Encyclopedia of DNA element projectRead MoreCharacteristics Of The Functional Area Of Human Genome2127 Words   |  9 Pagessegment of human genome is formed of protein sequences while some of the non coded DNA indicates biologica l functions. Along with the coding of genomes, they are also consisted of sequence which is transcript into RNA like tRNA, rRNA .New challenges of these sequences in the non protein are most prevalent. They are known to identify the functional area in the human genome which is studied by (ENCODE) project. The characteristics which are acting upon the regulatory variations amongst the human beingsRead MoreAnnotated Bibliography On The Landscape Of Transcription2715 Words   |  11 PagesLANDSCAPE OF TRANSCRIPTION IN HUMAN CELLS INTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and geneRead MoreThe Encyclopedia Of Dna Elements2709 Words   |  11 PagesINTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential outputRead MoreSilico Characterization Of The Association Between Rs12670798 And Ldl Cholesterol2868 Words   |  12 PagesIntroduction Complex diseases are caused by multiple genetic and environmental factors working in combination with each other and thus, it is difficult to characterise the contribution of any one factor to the disease1. However, the widespread adoption of genome-wide association studies (GWAS) has greatly accelerated the rate at which these factors are discovered and characterised. These studies genotype individuals with different phenotypes (for example, those who are affected or unaffected by a complex

The Human Genome Project And Encyclopedia Of Dna Elements

Understanding our life as we know it must start at the basics with our own DNA. DNA is the building blocks for all life, so to understand life we must analyze the mechanism of genetics. Projects like the Human Genome project and Encyclopedia of DNA elements (ENCODE) analyzes DNA to give society an interpretation of what the building code is and means. Our genetic code holds coding and non-coding sequences, at first researchers focused solely on coding DNA for it carried the function and means to life. The other non-coding was for years considered to be junk but in this review it will be highlighted by the example of Transposable elements that this so called useless DNA holds many secrets and keys to life. It is now recognized that genomic changes are influenced by transposable elements which has changed the way it is thought how genomes evolve and work. DNA Introduction Deoxyribonucleic acid, the building blocks for about all living creatures on Earth. Almost every cell in the human body shares the same DNA. Since DNA is practically the blueprint for living organisms, understanding the blueprint is crucial to a better understanding of the phenomena of our own bodies and the relationship between genetic variation and disease risk hopefully leading to the cure of many diseases, the prevention of harmful mutations, and possibly an explanation to our creation. This DNA is all the information for one’s body and is stored as a code with 4 chemical bases. As seen in theShow MoreRelatedEssay on The Human Genome Project1437 Words   |  6 Pagesdeeply in our body is the complex biological story. The Human Genome Project is the exploration of this intricate yet crucial storyline. The Genome is a complete set of genes that make up an organism. Genes are made up of DNA (deoxynucleic acid) which subsequently is made up of long paired strands. These paire d strands attach in a specific manner, for example, Adenine (A) attaches itself to Thymine (T) and Cytosine(C) to Guanine (G). The genome is the perplexing key in instructing cells to do theirRead MoreHow The Firm Strategy Affect The Emergence Of The Genomic Industry?1489 Words   |  6 Pagesanalysis of an individual’s genome. The industry can create a new avenue of approach in which it may profit through the production of tailored products and insights through the study of individual genome. This will also allow for the development of new technology and growth. Because of the necessity of a great quantity of diverse phenotypic and genomic data, this industry firm strategy will also consider genome databases and direct to consumer (DTC) genetic testing. Genome databases will give companiesRead MoreBiological Networks And The Biomedical And Genomic Fields962 Words   |  4 Pagesare ENCODE (Encyclopedia of DNA Elements) and TCGA (The Cancer Genome Atlas). The ENCODE project14, 15 was launched to identify all functional elements in the human genome - regions of transcription, transcription factor association, chromatin structure and histone modification. The ENCODE project has generated more than 6000 genomic datasets from ChIP-seq, RNA-seq, DNase-seq, shRNA knockdown followed by RNA-seq (The ENCODE Project Consortium, 2015). The pilot phase of the ENCODE project involved 440Read MoreThe Encyclopedia Of Dna Elements2407 Words   |  10 Pages The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential output from genomesRead MoreGenome Decoding: A Review of Three Articles1724 Words   |  7 Pagesthen states the reason why this newspaper gave a better version of the covered story among others based on the tendency (context), the information giving, and the supported arguments that this newspaper have. Genome Decoding: A review of three articles on the subject Introduction Genome Decoding is one of the most recent tantalizing scientific discoveries that have recently appeared in the news. Scientists have discovered that the 20,000 genes that do not code for proteins (and were, thereforeRead MoreAnnotated Bibliography On The Rna Profiling1999 Words   |  8 Pagesthe genome functions also. These observation are taken up together to form and define the functions and description related to genes (Bell, 2004). This observation tells about the range of expression and localization. As the technology is been improving day by day for the RNA profiling and the type of isolation made by the cells , the number of RNA has grown and has increase the biological function in an fast and immediate rate. The ENCODE project also known as the Encyclopedia of DNA element projectRead MoreCharacteristics Of The Functional Area Of Human Genome2127 Words   |  9 Pagessegment of human genome is formed of protein sequences while some of the non coded DNA indicates biologica l functions. Along with the coding of genomes, they are also consisted of sequence which is transcript into RNA like tRNA, rRNA .New challenges of these sequences in the non protein are most prevalent. They are known to identify the functional area in the human genome which is studied by (ENCODE) project. The characteristics which are acting upon the regulatory variations amongst the human beingsRead MoreAnnotated Bibliography On The Landscape Of Transcription2715 Words   |  11 PagesLANDSCAPE OF TRANSCRIPTION IN HUMAN CELLS INTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and geneRead MoreThe Encyclopedia Of Dna Elements2709 Words   |  11 PagesINTRODUCTION The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential outputRead MoreSilico Characterization Of The Association Between Rs12670798 And Ldl Cholesterol2868 Words   |  12 PagesIntroduction Complex diseases are caused by multiple genetic and environmental factors working in combination with each other and thus, it is difficult to characterise the contribution of any one factor to the disease1. However, the widespread adoption of genome-wide association studies (GWAS) has greatly accelerated the rate at which these factors are discovered and characterised. These studies genotype individuals with different phenotypes (for example, those who are affected or unaffected by a complex

Wednesday, May 6, 2020

Richard Iii/Looking for Richard Essay - 1179 Words

HSC Advanced English, Module A: Richard III and Looking For Richard, Essay Connections of commonality and dissimilarity may be drawn between a multiplicity of texts through an appreciation of the values and attitudes with which they were composed. Accordingly, the values and attitudes of the individual being may be defined as an acute blend of externally induced, or contextual and internally triggered, or inherent factors. Cultural, historical, political, religious and social influences, dictated by the nature of one’s surroundings, imprint a variable pattern of values and attitudes upon the individual. Thus any deviation in any such factor may instigate an alteration of the contextual component of one’s perspective. By contrast, the†¦show more content†¦This derives from the play as a recount of historical events with a known outcome and a medium for propaganda in support of the monarchy, an avid determinist. Nevertheless, the aforementioned tension is prevalent throughout and epitomised by the paradoxical pun ‘I am determined to prove a villain’. Uttered with a tone of poise and self-assuredness, the term ‘determined’ implies a conscious statement of purpose and a preordained villainy. Thus Richard is aligned with the stock character of the Vice, an instrument of predestination, and the innovative Machiavel, an advocator of humanism. Despite this, the ultimate decline of Richard is consequential of the reign of determinism. The directly antithetic correctio ‘I am a villain. Yet I lie, I am not’ yields an implicit self-doubt and acknowledgment of an inability to fulfil his humanist purpose. Providentialism thus displays precedence over self-determination. This is in direct contrast to Pacino’s docudrama, composed for a secular modern American audience disengaged with traditional notions of determinism. A greatly diminished and altered portrayal of Margaret, the primary instrument of determinism in the play, is expressive of this. Pacino devalues her curses by reduci ng her to a ‘sort of ghost of the past’. A frenzied montage of informative discourse and the activity of the play complete withShow MoreRelatedEssay on Richard Iii and Looking for Richard1284 Words   |  6 PagesA deeper understanding of ambition and identity emerges from pursuing the connections between King Richard III and Looking for Richard. Compare how these texts explore ambition and identity. Ambition; an earnest desire for some type of achievement or distinction, as power, honour, fame, or wealth, and the willingness to strive for its attainment * Al Pacino’s production as an art-house vanity project * Promotes himself – manipulating the audience through cutaways, specific and timedRead MoreKing Richard Iii and Looking for Richard Essay1602 Words   |  7 PagesEssay 1 – King Richard III and Looking for Richard How has your study of the connections between King Richard III and Looking for Richard deepened your understanding of the context of and values within, each text? William Shakespeare’s play King Richard III and Al Pacino’s docu-drama Looking for Richard have enriched my understanding of how context shapes the values inscribed within each text. In light of this, the connection that exists between the two texts is: how the central character of theRead MoreKing Richard Iii and Looking for Richard Essay2197 Words   |  9 PagesThe texts King Richard III and Looking for Richard both accept the centrality of power and the yearning for it, as a central plot driver and an assumed part of the human condition. However, each presents a different perspective as to the nature of power; its origins and morality. Discuss this statement with close, detailed reference to both texts set for study. Power is defined as the possession of control or command over people and events. In Shakespeare’s play ‘King Richard III’, the centralityRead MoreKing Richard Iii and Looking for Richard Essay Plan1162 Words   |  5 PagesShakespeare’s Richard III and Al Pacino’s Looking for Richard both portray central values and ideas of the time. * The texts ideas are reflected by the context of the time. * Both texts written in different time periods meaning completely different contexts which shape the text. * Through Pacino’s hybrid style docudrama, he attempts to demystify Shakespeare’s Richard III, making it more accessible to the everyday person. * Shakespeare shows the journey in Richard III of Richard himselfRead MorePaper 2: Module a Richard Iii/Looking for Richard1020 Words   |  5 Pages Through exploring connections between Shakespeare’s Richard III and Al Pacino’s Looking for Richard the values of the era are often a product of the context of the text. However, through studying the theatricality of man and the pursuit of power, it is clear these notions transcend time and context. Shakespeare valued the way an actor could act within a play and theatre was valued in this context. Shakespeare also demonstrated how Richard pursued political power, whilst Shakespeare himself pursuedRead MoreNotes on King Richard Iii and Looking for Richard Essay1350 Words   |  6 Pagesever a woman in the humour won?† - assonance and expansive ‘o’ sounds as well as rhetoric and repetition â€Å"I’ll have her but I’ll not keep her long† - intercuts of ‘Ha’ as well as an increased speed of cuts through this line – almost portrays Richard as mad – cut of him out of costume in rehearsal laughing - Seduction through language and sexual tension in Pacino’s version – low neckline in costume, attempted kiss- more recognised and understood by audience, romantic model of film - no diageticRead MoreEssay about Richard Iii + Looking for Richard Comparative Speech834 Words   |  4 PagesGood morning/afternoon Throughout my comparative study of texts and context, I have explored various connections shared between William Shakespeare’s ‘Richard the 3rd’ and Al Pacino’s ‘Looking for Richard’. As both of these items are based on the same character, King Richard the 3rd, they share a lot in common. The connection that I have chosen to concentrate on though is the idea of power, and how both texts explore this theme. William Shakespeare is an extremely famous EnglishRead MoreAnalyse How the Central Values Portrayed in King Richard Iii Are Creatively Reshaped in Looking for Richard.1683 Words   |  7 PagesAn honest tale speeds best, being plainly told.† This quote from William Shakespeare’s King Richard III is a seed from which Al Pacino’s docu-drama Looking For Richard grows, both texts demonstrating the intrinsic relationship between contexts and the composition of texts. As 21st century students, we see Pacino’s creative reshaping emphasise inherent values within the original text, from dynamic perspectives to interpretational understandings, presented in an ‘honest’ and ‘plainly told’ compositionRead MoreJane Eyre1260 Words   |  6 Pagesbetween King Richard III and Looking For Richard is further enhanced by consideration of the marked differences in textual form. Evaluate this statement in the light of your Comparative Study of King Ri chard III and Looking For Richard. William Shakespeare’s 16th century historically tragic play, King Richard III and Al Pacino’s 20th century docudrama, Looking for Richard portray parallel themes of war, characterisation of Richard in context and plot. Shakespeare wrote King Richard III during theRead MoreWilliam Shakespeare s King Richard IIi1258 Words   |  6 PagesRichard: What have you done to me! Shakespeare: My historical tragedy â€Å"King Richard III† is just my dramatic presentation of your exploits in your bloody pursuit of the throne. Pacino: My postmodernist docudrama â€Å"Looking for Richard† is my modern interpretation of Richard III. My attempt to establish connections that enhance our understandings and interpretations of our respective contexts, ideas and values, primarily involving the representation of the human condition through the character of Richard

Tuesday, May 5, 2020

Confidentiality and Managed Care Ethical and Legal

Question: Discuss about the Confidentiality and Managed Care for Ethical and Legal. Answer: Introduction: This is where a patient refuses treatment after the doctor has educated the patient of the diagnosis, prognosis, accessible other interventions, risks and benefits of those options, and risk and probable outcome of no intervention (Lo, at al,2011). The patient needs to be in his rightful mind at the time of refusing treatment, he should not be mentally ill, intoxicated drunk or on drugs at the time of making this crucial decision. This is where patient who does not take a prescribed medication or does not follow a prescribed course of treatment (Donovan, at al, 2010). Course of action that would be most appropriate for Refusal for treatment and Non compliance Where the patient refuses treatment the doctor has an option of providing involuntary treatment. The treatment is usually given by injection or by mouth, but only to control the emergency and the doctor stops administering the involuntary treatment once the patient is out of imminent danger. As for non-compliance the doctor can carry out a discussion with the non-compliant patient on his problem and the steps the patient can take to resolve his problem. Ethical issues that arise related to the patient's right to a confidential therapeutic relationship and the family caregiver's right to information (Davidson, at al, 2012) The health care provider may share or discuss only the information that the person involved needs to know about the patients care or payment for care. The healthcare provider is not supposed to give out the information of the patient without the patients consent. How are the above issues addressed by the Mental Health Act in your State? The mental Act provides for the right of confidentiality where the care giver is supposed to keep the information of the patient confidential. He is not supposed to disclose this information except with the permission of the patient (Donovan, at al. 2006). References Davidson, J.R. and Davidson, T., 2012. Confidentiality and managed care: Ethical and legal concerns. Health Social Work, 21(3), pp.208-215. Donovan, J.L. and Blake, D.R., 2010. Patient non-compliance: deviance or reasoned decision-making?. Social science medicine, 34(5), pp.507-513. Donovan, R.J., James, R., Jalleh, G. and Sidebottom, C., 2006. Implementing Mental Health Promotion: The ActBelongCommit Mentally Healthy WA Campaign in Western Australia. International Journal of Mental Health Promotion, 8(1), pp.33-42. Lo, B., McLeod, G.A. and Saika, G., 2011. Patient attitudes to discussing life-sustaining treatment. Archives of internal medicine, 146(8), pp.1613-1615.